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Title: Six Things Suppress Testosterone Besides Age. Dr. John Spencer Ellis Says Men Should Know Which Ones Apply Before Deciding About TRT.

Las Vegas, Nevada, United States, 4th Sep 2026 — A 49-year-old man returns a testosterone result of 340 ng/dL and has a decision to make. What Dr. John Spencer Ellis wants him to understand is that he does not yet have enough information to make it."A low number tells you the level. It does not tell you the cause," said the internationally recognized authority on men's health, longevity and human performance. "In medicine that is called a differential diagnosis, and low testosterone has one. Six things suppress it besides age. Knowing which apply to you is what turns a guess into a decision."He is emphatic about what he is not saying."I am not telling men to avoid TRT. It is an FDA-approved therapy, it works, and the 2023 TRAVERSE trial of 5,246 men found it noninferior to placebo for major adverse cardiac events — which settled a decade-old cardiovascular controversy and led the FDA to remove the warning from testosterone labeling in 2025. For men who genuinely need it, it is excellent medicine. I am saying: work the differential first."The six1. Sleep. The most direct evidence in the field, and the most overlooked. A JAMA paper by Leproult and Van Cauter states plainly that the majority of the daily testosterone release in men occurs during sleep. The researchers restricted ten healthy young men to under five hours nightly for one week and measured significantly lower testosterone — a reduction commonly cited at 10 to 15 percent, in men in their twenties, from seven days."Extrapolate that to four years of six broken hours in a 50-year-old," said Dr. Ellis. "The paper's senior author called short sleep an endocrine disruptor. That is not rhetoric."2. Obstructive sleep apnea, which is separately associated with reduced testosterone, is comm...

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